BDBM50297306 CHEMBL540982::{2-[3-(4-Fluoro-benzyl)-benzo[b]thiophen-2-yl]-ethyl}-dimethyl-amine

SMILES CN(C)CCc1sc2ccccc2c1Cc1ccc(F)cc1

InChI Key InChIKey=AWYSEPZPTVMKBT-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297306   

TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297306({2-[3-(4-Fluoro-benzyl)-benzo[b]thiophen-2-yl]-eth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant CYP2D6 in presence of NADPH generating systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297306({2-[3-(4-Fluoro-benzyl)-benzo[b]thiophen-2-yl]-eth...)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297306({2-[3-(4-Fluoro-benzyl)-benzo[b]thiophen-2-yl]-eth...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297306({2-[3-(4-Fluoro-benzyl)-benzo[b]thiophen-2-yl]-eth...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed