BDBM50297304 CHEMBL560741::{2-[3-(4-Fluoro-benzyl)-1H-inden-2-yl]-ethyl}-dimethyl-amine

SMILES CN(C)CCC1=C(Cc2ccc(F)cc2)c2ccccc2C1

InChI Key InChIKey=FRXWLMMHSBOBJK-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50297304   

TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297304({2-[3-(4-Fluoro-benzyl)-1H-inden-2-yl]-ethyl}-dime...)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant CYP2D6 in presence of NADPH generating systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297304({2-[3-(4-Fluoro-benzyl)-1H-inden-2-yl]-ethyl}-dime...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297304({2-[3-(4-Fluoro-benzyl)-1H-inden-2-yl]-ethyl}-dime...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed