BDBM50296881 (1-((1R,4R)-4-((S)-2,2-difluoro-1-(4-methoxyphenyl)ethylamino)-2,2-dimethylcyclohexanecarbonyl)-4-phenylpiperidin-4-yl)(pyrrolidin-1-yl)methanone::CHEMBL540466

SMILES COc1ccc(cc1)[C@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(CC2)(C(=O)N2CCCC2)c2ccccc2)C(C)(C)C1)C(F)F

InChI Key InChIKey=ZSNMPXARMQLVQF-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50296881   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296881((1-((1R,4R)-4-((S)-2,2-difluoro-1-(4-methoxyphenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [35S]MK499 from human ERG potassium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296881((1-((1R,4R)-4-((S)-2,2-difluoro-1-(4-methoxyphenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human neuropeptide Y4 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296881((1-((1R,4R)-4-((S)-2,2-difluoro-1-(4-methoxyphenyl...)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human neuropeptide Y2 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296881((1-((1R,4R)-4-((S)-2,2-difluoro-1-(4-methoxyphenyl...)
Affinity DataIC50: 280nMAssay Description:Antagonist activity at human neuropeptide Y1 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296881((1-((1R,4R)-4-((S)-2,2-difluoro-1-(4-methoxyphenyl...)
Affinity DataIC50: 4.80E+3nMAssay Description:Displacement of [3H]imipramine from human serotonin transporter expressed in CHO cell membrane by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 5(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296881((1-((1R,4R)-4-((S)-2,2-difluoro-1-(4-methoxyphenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mouse neuropeptide Y5 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296881((1-((1R,4R)-4-((S)-2,2-difluoro-1-(4-methoxyphenyl...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed