BDBM50296234 (-)-epigallocatechin-3-(3''-O-methyl)gallate::(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4-dihydroxy-5-methoxybenzoate::CHEMBL562716::US20240336588, Compound 8

SMILES COc1cc(cc(O)c1O)C(=O)O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1

InChI Key InChIKey=WVRDOLPMKOCJRJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50296234   

TargetMatrix metalloproteinase-14(Human)
University of Shizuoka and Global Coe Program

Curated by ChEMBL
LigandPNGBDBM50296234((2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)ch...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant MT1-MMP expressed in Escherichia coli by fluorogenic peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Shizuoka and Global Coe Program

Curated by ChEMBL
LigandPNGBDBM50296234((2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)ch...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP7 expressed in Escherichia coli by fluorogenic peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Shizuoka and Global Coe Program

Curated by ChEMBL
LigandPNGBDBM50296234((2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)ch...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human recombinant MMP2 expressed in Escherichia coli by fluorogenic peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50296234((2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)ch...)
Affinity DataIC50: 429nMAssay Description:Inhibition of DYRK1A (unknown origin) using HT-497 as substrate preincubated with compound followed by substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50296234((2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)ch...)
Affinity DataIC50: 100nMAssay Description:DYRK1A assay. Substrate, HT-PRD (Proline rich domain, residues 746-864 of dynamin 1a, prepared as N-terminal tagged 6×His fusion protein), was dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent