BDBM50296189 1-{3-[4-(3-Methyl-4,4-dioxo-4H-4lambda*6*-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-pyrrolidine::CHEMBL556100

SMILES CC1=C(Oc2ccccc2S1(=O)=O)c1ccc(OCCCN2CCCC2)cc1

InChI Key InChIKey=KIJIJUXKXSTTLC-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50296189   

TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296189(1-{3-[4-(3-Methyl-4,4-dioxo-4H-4lambda*6*-benzo[1,...)
Affinity DataIC50: 0.840nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylhistamine-induced [35S]GTPgammaS binding by ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296189(1-{3-[4-(3-Methyl-4,4-dioxo-4H-4lambda*6*-benzo[1,...)
Affinity DataIC50: 470nMAssay Description:Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296189(1-{3-[4-(3-Methyl-4,4-dioxo-4H-4lambda*6*-benzo[1,...)
Affinity DataIC50: 470nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296189(1-{3-[4-(3-Methyl-4,4-dioxo-4H-4lambda*6*-benzo[1,...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed