BDBM50296146 CHEMBL557921::ethyl 4-(3-(2-chlorophenyl)-1-(2,4-dimethylphenyl)-1H-pyrazole-5-carbonyl)piperazine-1-carboxylate

SMILES CCOC(=O)N1CCN(CC1)C(=O)c1cc(nn1-c1ccc(C)cc1C)-c1ccccc1Cl

InChI Key InChIKey=VFWKLRQPRKIPLU-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296146   

TargetCannabinoid receptor 1(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296146(ethyl 4-(3-(2-chlorophenyl)-1-(2,4-dimethylphenyl)...)
Affinity DataEC50:  200nMAssay Description:Inverse agonist activity at human CB1 receptor by [35S]GTPgammaS incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296146(ethyl 4-(3-(2-chlorophenyl)-1-(2,4-dimethylphenyl)...)
Affinity DataKi:  287nMAssay Description:Displacement of [3H]rimonabant from human CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296146(ethyl 4-(3-(2-chlorophenyl)-1-(2,4-dimethylphenyl)...)
Affinity DataKi:  1.07E+3nMAssay Description:Displacement of [3H]rimonabant from human CB2 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed