BDBM50296144 2-(7,7-dimethyl-2-p-tolyl-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-ylthio)-N-(2-methoxyphenyl)propanamide::CHEMBL560463

SMILES COc1ccccc1NC(=O)C(C)Sc1nc(nc2CC(C)(C)OCc12)-c1ccc(C)cc1

InChI Key InChIKey=SSICYFCGLBBCKU-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296144   

TargetCannabinoid receptor 1(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296144(2-(7,7-dimethyl-2-p-tolyl-7,8-dihydro-5H-pyrano[4,...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inverse agonist activity at human CB1 receptor by [35S]GTPgammaS incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296144(2-(7,7-dimethyl-2-p-tolyl-7,8-dihydro-5H-pyrano[4,...)
Affinity DataKi:  264nMAssay Description:Displacement of [3H]rimonabant from human CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296144(2-(7,7-dimethyl-2-p-tolyl-7,8-dihydro-5H-pyrano[4,...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]rimonabant from human CB2 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed