BDBM50296009 2-ethyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid::CHEMBL550110

SMILES CCc1cc(ccc1C(O)=O)-c1c[nH]c2ncc(cc12)-c1ccccc1

InChI Key InChIKey=FXLKAGSPCQYANT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296009   

TargetSerine/threonine-protein kinase Sgk1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50296009(2-ethyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50296009(2-ethyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)...)
Affinity DataIC50: 710nMAssay Description:Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50296009(2-ethyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of full-length human GST-tagged CAMKK2 using 5FAM-AKPKGNKDYHLQTCCGSLAYRRR-amide as substrate preincubated for 30 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed