BDBM50295762 CHEMBL550158::tert-butyl 4-(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-pyrrolo[3,2-b]pyridin-6-yl)piperazine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12

InChI Key InChIKey=JKYGLDWVDXTXJE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50295762   

TargetHepatocyte growth factor receptor(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295762(tert-butyl 4-(1-(6-chloroimidazo[2,1-b]thiazol-5-y...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295762(tert-butyl 4-(1-(6-chloroimidazo[2,1-b]thiazol-5-y...)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295762(tert-butyl 4-(1-(6-chloroimidazo[2,1-b]thiazol-5-y...)
Affinity DataIC50: 110nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295762(tert-butyl 4-(1-(6-chloroimidazo[2,1-b]thiazol-5-y...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed