BDBM50295566 3-[4'-(4''-Cyanophenyl)benzoyl]-3,4-dihydro-8-methyl-2H-pyrido[1,2-a]pyrimidine hydrochloride

SMILES Cc1ccn2CC(CN[c+]2c1)C(=O)c1ccc(cc1)-c1ccc(cc1)C#N

InChI Key InChIKey=AVZTWJDPZASEBQ-UHFFFAOYSA-O

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50295566   

TargetNitric oxide synthase, inducible(Mouse)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50295566(3-[4'-(4''-Cyanophenyl)benzoyl]-3,4-dihydro-8-meth...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as NADPH consumption after 2 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50295566(3-[4'-(4''-Cyanophenyl)benzoyl]-3,4-dihydro-8-meth...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50295566(3-[4'-(4''-Cyanophenyl)benzoyl]-3,4-dihydro-8-meth...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioactiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50295566(3-[4'-(4''-Cyanophenyl)benzoyl]-3,4-dihydro-8-meth...)
Affinity DataIC50: 1.28E+5nMAssay Description:Inhibition of rat recombinant nNOS expressed in Saccharomyces cerevisiae assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed