BDBM50295542 4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-yl)-1,2,4-oxadiazol-3-yl)benzoic acid::CHEMBL559531

SMILES OC(=O)c1ccc(cc1)-c1noc(n1)C1CCN(CC1)C(=O)NC1CC1c1ccccc1

InChI Key InChIKey=ACXQPBJHXILGLA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50295542   

TargetBifunctional epoxide hydrolase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human sEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Nav1.5 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Cav 1.2 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKr channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetEpoxide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295542(4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human mEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed