BDBM50295294 (+/-)-trans-3-(2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile::3-((1S,2S)-2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile::CHEMBL552167::trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile

SMILES CN(C)C[C@H]1CCC[C@@H]1c1c[nH]c2ccc(cc12)C#N

InChI Key InChIKey=RXJIAQGHWRMBEZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50295294   

TargetSodium-dependent serotonin transporter(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 690nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 7.90E+3nMAssay Description:Displacement of [125I]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 0.130nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 690nMAssay Description:Displacement of [I125]RTI-55 from human DAT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 7.90E+3nMAssay Description:Displacement of [125I]nisoxetine from human NET transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 0.130nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed