BDBM50294835 4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-methyl-N-quinolin-8-yl-benzamide::CHEMBL551505::CHEMBL562310::N-(Quinolin-8-yl)-4-(endo-4-aza-3,5-dioxotricyclo[5.2.1.02,6]oct-8-en-4-yl)benzamide, 1

SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12

InChI Key InChIKey=OGYSABKWWQZOIU-UHFFFAOYSA-N

Data  14 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50294835   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 131nMAssay Description:Inhibition of TNKS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 29nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 303nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of PARP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human PARP2 using NAD+ as substrate after 90 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human PARP1 using NAD+ as substrate after 90 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataEC50:  5.00E+3nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataEC50:  200nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProtein Wnt-2(Mouse)
University of Texas Southwestern Medical Center

LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 58nMpH: 7.4 T: 2°CAssay Description:Inhibition assay of Wnt response treated with exogenously supplied of Wnt protein ('exogenous Wnt' test)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of N-terminal His6-tagged human TNKS2 (946 to 1162 amino acid residues) after 60 mins by autoparsylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 151nMAssay Description:Inhibition of N-terminal His6-tagged human TNKS1 (1091 to 1325 amino acid residues) after 60 mins by autoparsylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of PARP2 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of PARP1 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProto-oncogene Wnt-3(Human)
The University of Texas Southwestern Medical Center At Dallas

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed