BDBM50294675 CHEMBL565076::N,1-dimethyl-7-phenyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine

SMILES CNc1nc2[nH]c(cc2c2n(C)cnc12)-c1ccccc1

InChI Key InChIKey=REPJKBLVQPPXEF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50294675   

TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50294675(N,1-dimethyl-7-phenyl-1,6-dihydroimidazo[4,5-d]pyr...)
Affinity DataIC50: 40nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50294675(N,1-dimethyl-7-phenyl-1,6-dihydroimidazo[4,5-d]pyr...)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of IKK2-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50294675(N,1-dimethyl-7-phenyl-1,6-dihydroimidazo[4,5-d]pyr...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed