BDBM50294624 CHEMBL541020::N-[(1S,2R)-1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-3-(1,1-dioxo-1lambda*6*-[1,2]thiazinan-2-yl)-5-{1-[methoxyimino]-ethyl}-benzamide

SMILES CO\N=C(\C)c1cc(cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(OC)c1)N1CCCCS1(=O)=O

InChI Key InChIKey=NOHSCRMBTHXJAZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50294624   

TargetBeta-secretase 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50294624(N-[(1S,2R)-1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-...)
Affinity DataIC50: 52nMAssay Description:Binding affinity to BACE assessed as displacement of [3H]BMS-599240More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50294624(N-[(1S,2R)-1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-...)
Affinity DataIC50: 345nMAssay Description:Inhibition of BACE1 in human HEK293 cells overexpressing APP with Swedish mutation assessed as inhibition of amyloid beta 40 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed