BDBM50293856 1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1'-spirocyclopropane(bicyclo[2.2.1]heptane)-1'-norbornylmethyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one hydrochloride::CHEMBL563980

SMILES OC[C@@H](O)Cn1c2ccccc2n(C2CCN(C[C@H]3[C@H]4CC[C@H](C4)C33CC3)CC2)c1=O

InChI Key InChIKey=DTAPURRKADLRKH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50293856   

TargetDelta-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naltrindole from human cloned delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 2.70E+3nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 6.80E+3nMAssay Description:Displacement of [3H]U69593 from human cloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed