BDBM50293643 CHEMBL551958::N-cyclopentyl-6-(2-phenylethynyl)nicotinamide

SMILES O=C(NC1CCCC1)c1ccc(nc1)C#Cc1ccccc1

InChI Key InChIKey=GKYRUZWYDPUSOV-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50293643   

TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293643(N-cyclopentyl-6-(2-phenylethynyl)nicotinamide | CH...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293643(N-cyclopentyl-6-(2-phenylethynyl)nicotinamide | CH...)
Affinity DataEC50:  19nMAssay Description:Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as increase of L-glutamate-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293643(N-cyclopentyl-6-(2-phenylethynyl)nicotinamide | CH...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [3H]MPEP from human recombinant mGluR5 expressed in BHK cells at by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293643(N-cyclopentyl-6-(2-phenylethynyl)nicotinamide | CH...)
Affinity DataKi:  3.30E+3nMAssay Description:Displacement of [3H]-MPEP from human mGluR5 expressed in HEK293 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed