BDBM50293521 CHEMBL550482::N-(1-methyl-1H-indazol-5-yl)-2-(6-methylpyridin-2-yl)quinazolin-4-amine

SMILES Cc1cccc(n1)-c1nc(Nc2ccc3n(C)ncc3c2)c2ccccc2n1

InChI Key InChIKey=SBPSWNGBIYLPSD-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50293521   

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293521(N-(1-methyl-1H-indazol-5-yl)-2-(6-methylpyridin-2-...)
Affinity DataIC50: 588nMAssay Description:Inhibition of human ALK5 kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293521(N-(1-methyl-1H-indazol-5-yl)-2-(6-methylpyridin-2-...)
Affinity DataIC50: 794nMAssay Description:Inhibition of TGF-beta-induced ALK5 in human HepG2 cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293521(N-(1-methyl-1H-indazol-5-yl)-2-(6-methylpyridin-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-fused p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293521(N-(1-methyl-1H-indazol-5-yl)-2-(6-methylpyridin-2-...)
Affinity DataKd:  5.50E+3nMAssay Description:Binding affinity to wild type human partial length TGFBR1 (D179 to M503 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed