BDBM50293520 CHEMBL537968::N-(1H-indazol-5-yl)-2-(6-methylpyridin-2-yl)quinazolin-4-amine::N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine

SMILES Cc1cccc(n1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1

InChI Key InChIKey=HNHRWNUXTCATSG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293520   

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293520(N-(1H-indazol-5-yl)-2-(6-methylpyridin-2-yl)quinaz...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human ALK5 kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293520(N-(1H-indazol-5-yl)-2-(6-methylpyridin-2-yl)quinaz...)
Affinity DataIC50: 90nMAssay Description:Inhibition of TGF-beta-induced ALK5 in human HepG2 cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293520(N-(1H-indazol-5-yl)-2-(6-methylpyridin-2-yl)quinaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-fused p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed