BDBM50293515 2-(4-methylthiazol-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine::CHEMBL541777

SMILES Cc1csc(n1)-c1nc(Nc2ccncc2)c2ccccc2n1

InChI Key InChIKey=NBMFKJACAZPWPF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293515   

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293515(2-(4-methylthiazol-2-yl)-N-(pyridin-4-yl)quinazoli...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human ALK5 kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293515(2-(4-methylthiazol-2-yl)-N-(pyridin-4-yl)quinazoli...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of GST-fused p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293515(2-(4-methylthiazol-2-yl)-N-(pyridin-4-yl)quinazoli...)
Affinity DataIC50: 342nMAssay Description:Inhibition of TGF-beta-induced ALK5 in human HepG2 cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed