BDBM50293361 CHEMBL561209::N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide

SMILES COc1ccc(cc1)-c1ccc(\C=C\C(=O)NO)cc1

InChI Key InChIKey=WKQPXLKFQLGQSM-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50293361   

TargetHistone deacetylase 2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of human HDAC9 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of human HDAC11 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of human HDAC3 complexed with NCOR2 using fluorogenic tetrapeptide RHKKAc as susbtrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 8.55E+3nMAssay Description:Inhibition of human HDAC1 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 9.90E+4nMAssay Description:Inhibition of human HDAC4 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 2.10E+5nMAssay Description:Inhibition of human HDAC7 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human HDAC5 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of HDAC in human HeLa cells using BOC-Ac-Lys-AMC as substrate incubated for 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 3.26E+4nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using BOC-Ac-Lys-AMC as substrate incubated for 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293361(N-Hydroxy-E-3-(4'-methoxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of HDAC2 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed