BDBM50293358 CHEMBL556332::N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide

SMILES ONC(=O)\C=C\c1ccc(cc1)-c1ccc(O)cc1

InChI Key InChIKey=MGGQEULGVBEMAL-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50293358   

TargetHistone deacetylase 2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 590nMAssay Description:Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human HDAC5 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of human HDAC3 complexed with NCOR2 using fluorogenic tetrapeptide RHKKAc as susbtrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of human HDAC11 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 5.51E+3nMAssay Description:Inhibition of human HDAC1 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 8.92E+3nMAssay Description:Inhibition of human HDAC9 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human HDAC7 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human HDAC4 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 590nMAssay Description:Inhibition of HDAC2 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50293358(N-Hydroxy-E-3-(4'-hydroxybiphenyl-4-yl)-acrylamide...)
Affinity DataIC50: 590nMAssay Description:Inhibition of Homo sapiens (human) HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article