BDBM50293160 4-(6-isopropoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine::CHEMBL496162

SMILES CC(C)Oc1ccc2c(cnn2n1)-c1ccnc(Nc2ccc(cc2)N2CCN(C)CC2)n1

InChI Key InChIKey=AJLPDJZYNSSQJO-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50293160   

TargetCyclin-dependent kinase 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293160(4-(6-isopropoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(4...)
Affinity DataIC50: 45nMAssay Description:Inhibition of CDK4 by radioactive glutathione plate-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293160(4-(6-isopropoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(4...)
Affinity DataIC50: 850nMAssay Description:Inhibition of GSK3-beta by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293160(4-(6-isopropoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(4...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human CDK2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVenus kinase receptor 2(Blood fluke)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50293160(4-(6-isopropoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(4...)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to Schistosoma mansoni N-terminal His6-tagged full-length VKR2 kinase domain expressed in baculovirus infected Sf9 insect cells in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetVenus kinase receptor 2(Blood fluke)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50293160(4-(6-isopropoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(4...)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of Schistosoma mansoni N-terminal His6-tagged full-length VKR2 kinase domain expressed in baculovirus infected Sf9 insect cells assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed