BDBM50293157 4-(4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-ylamino)benzoic acid::CHEMBL524059

SMILES OC(=O)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1

InChI Key InChIKey=VSZVMUGJWVQEOS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293157   

TargetCyclin-dependent kinase 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293157(4-(4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl...)
Affinity DataIC50: 790nMAssay Description:Inhibition of CDK4 by radioactive glutathione plate-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293157(4-(4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of GSK3-beta by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293157(4-(4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human CDK2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed