BDBM50293015 CHEMBL502503::Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)amino-carbonyl)-2-(quinoline-2-carbonylamino)benzoate

SMILES COC(=O)c1ccc(cc1NC(=O)c1ccc2ccccc2n1)C(=O)Nc1ccc(CCN2CCc3cc(OC)c(OC)cc3C2)cc1

InChI Key InChIKey=FCDNRJDHYPWDHC-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50293015   

TargetATP-dependent translocase ABCB1(Human)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of ABCB1 expressed in Kb-V1 cells after 10 mins by calcein-AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataIC50: 59nMAssay Description:Inhibition of ABCG2 expressed in human MCF7/Topo cells by Hoechst microplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataIC50: 65nMAssay Description:Inhibition of ABCG2 in human MCF7/Topo cells after 2 hrs by Hoechst 33342 microplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of ABCB1 in human KBV1 cells after 10 mins by flow cytometric calcein-AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataIC50: 60nMAssay Description:Inhibition of ABCG2 overexpressed in human MCF7/Topo cells by flow cytometric-based mitoxantrone efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of ABCC2 overexpressed in MDCK cells at 100 uM by flow cytometric-based chloromethylfluorescein-diacetate accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of ABCB1 overexpressed in human KBv1 cells by flow cytometric-based calcein-AM efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataIC50: 101nMAssay Description:Inhibition of ABCG2 in topotecan-cultured human MCF7 cells using Hoechst 33342 as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataEC50:  105nMAssay Description:Activation of ABCB1 ATPase activity (unknown origin) expressed in baculovirus infected Sf9 insect cells using ATP as substrate measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293015(Methyl 4-((4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydroi...)
Affinity DataIC50: 294nMAssay Description:Inhibition of sulfasalazine-stimulated ABCB1 ATPase activity (unknown origin) expressed in baculovirus infected Sf9 insect cells using ATP as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed