BDBM50292920 17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy-6beta-[(4'-pyridyl)acetamido]morphinan::CHEMBL522143

SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)c1ccncc1

InChI Key InChIKey=XQWZTPWKACKUMJ-UHFFFAOYSA-N

Data  5 KI  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50292920   

TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to wild type mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]-GTP-gammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataEC50:  1.10nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataEC50:  29nMAssay Description:Agonist activity at kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]-GTP-gammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at MOR (unknown origin) assessed as inhibition of DAMGO-induced agonismMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to wild type MOR (unknown origin) expressed in CHO cells after 15 mins by Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]naloxone from monocloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to wild type MOR (unknown origin) expressed in CHO cells after 15 mins by Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  4.80nMAssay Description:Antagonist activity at mu-opioid receptor in rat thalamus membrane assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding incubated for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]norBNI from monocloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292920(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  278nMAssay Description:Displacement of [3H]NTI from monocloned delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed