BDBM50292630 (23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxyvitaminD3-26,23-lactone::(5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methylene-9,10-secoestra-5,7-dien-17-yl]propyl}-3-methylenedihydro-2(3H)-furanone::CHEMBL261197

SMILES [#6]-[#6@H](-[#6]-[#6@@H]-1-[#6]-[#6](=[#6])-[#6](=O)-[#8]-1)-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1

InChI Key InChIKey=TVQCSHDUZNHJQU-UHFFFAOYSA-N

Data  1 KI  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50292630   

TargetVitamin D3 receptor(Rat)
University of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50292630((5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methyle...)
Affinity DataEC50:  100nMAssay Description:Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50292630((5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methyle...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human VDR in HEK293 cells assessed as induction of transcriptional transactivation after 24 hrs by mouse osteopontin luciferase r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVitamin D3 receptor(Rat)
University of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50292630((5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methyle...)
Affinity DataEC50:  20nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from rat recombinant His-tagged VDR ligand-binding domain expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50292630((5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methyle...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human VDR in COS7 cells assessed as induction of transcriptional transactivation after 24 hrs by mouse osteopontin luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50292630((5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methyle...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human VDR in COS7 cells assessed as induction of transcriptional transactivation after 24 hrs by mouse osteopontin luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50292630((5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methyle...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human VDR in HEK293 cells assessed as induction of transcriptional transactivation after 24 hrs by mouse osteopontin luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVitamin D3 receptor(Rat)
University of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50292630((5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methyle...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]1-alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed