BDBM50291734 CHEMBL4159247

SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(C)cccc2F)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c1=O

InChI Key InChIKey=DSULJAVTIQEPAU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50291734   

TargetGonadotropin-releasing hormone receptor(Human)
Tiumbio

Curated by ChEMBL
LigandPNGBDBM50291734(CHEMBL4159247)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells co-expressing pGL4-NFATpromoter AP-1-luc assessed as inhibition of GnRH-induced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Tiumbio

Curated by ChEMBL
LigandPNGBDBM50291734(CHEMBL4159247)
Affinity DataIC50: 0.580nMAssay Description:Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cells after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Tiumbio

Curated by ChEMBL
LigandPNGBDBM50291734(CHEMBL4159247)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cells after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50291734(CHEMBL4159247)
Affinity DataIC50: 590nMAssay Description:Antagonist activity at rat GnRH receptor expressed in HEK293 cells co-expressing pGL4-NFATpromoter AP-1-luc assessed as inhibition of GnRH-induced NF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details Article
PubMed