BDBM50291005 5-Oxo-6-phenylmethanesulfonylamino-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid (1-carbamimidoyl-2-hydroxy-piperidin-3-yl)-amide::CHEMBL112727

SMILES NC(=N)N1CCC[C@H](NC(=O)C2CS[C@H]3CC[C@H](NS(=O)(=O)Cc4ccccc4)C(=O)N23)C1O

InChI Key InChIKey=XYHQRSYCQQCWPT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50291005   

TargetPlasminogen(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291005(5-Oxo-6-phenylmethanesulfonylamino-hexahydro-thiaz...)
Affinity DataIC50: 923nMAssay Description:In vitro inhibitory concentration required to inhibit human serine protease enzyme plasmin by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetProthrombin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291005(5-Oxo-6-phenylmethanesulfonylamino-hexahydro-thiaz...)
Affinity DataIC50: 16nMAssay Description:In vitro inhibitory concentration required to inhibit human serine protease enzyme thrombin (FIIa) by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSerine protease 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291005(5-Oxo-6-phenylmethanesulfonylamino-hexahydro-thiaz...)
Affinity DataIC50: 12nMAssay Description:In vitro inhibitory concentration required to inhibit human serine protease enzyme human trypsin by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCoagulation factor X(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291005(5-Oxo-6-phenylmethanesulfonylamino-hexahydro-thiaz...)
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibitory concentration required to inhibit Coagulation factor X by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article