BDBM50290389 CHEMBL295462::Methyl-carbamic acid 1-(3-fluoro-pyridin-4-ylamino)-3-methyl-1H-indol-5-yl ester

SMILES CNC(=O)Oc1ccc2n(Nc3ccncc3F)cc(C)c2c1

InChI Key InChIKey=GUHMRCCRDRBMHO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50290389   

TargetAcetylcholinesterase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50290389(Methyl-carbamic acid 1-(3-fluoro-pyridin-4-ylamino...)
Affinity DataIC50: 130nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCholinesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290389(Methyl-carbamic acid 1-(3-fluoro-pyridin-4-ylamino...)
Affinity DataIC50: 190nMAssay Description:In vitro inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.15-0.22More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetAcetylcholinesterase(Human)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50290389(Methyl-carbamic acid 1-(3-fluoro-pyridin-4-ylamino...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human AChE by Ellmans testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed