BDBM50290149 CHEMBL4174883

SMILES NC1=NC2(CCCCC2)N(C(N)=N1)c1ccc(OCc2cn(CCCOc3ccc4ccc(=O)oc4c3)nn2)cc1

InChI Key InChIKey=NXZUMNOHBRHSNU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50290149   

TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50290149(CHEMBL4174883)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis His-tagged DHFR assessed as reduction in consumption of NADPH using DHF as substrate measured every 30 secs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2020
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50290149(CHEMBL4174883)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using DHF as substrate measured every 30 secs over 6 mins by spect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2020
Entry Details Article
PubMed