BDBM50290047 CHEMBL308088::Pyridin-2-yl-carbamic acid 2-[6-(5-isopropyl-pyridine-2-sulfonylamino)-5-(2-methoxy-phenoxy)-2-thiomorpholin-4-yl-pyrimidin-4-yloxy]-ethyl ester

SMILES COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cn2)C(C)C)nc(nc1OCCOC(=O)Nc1ccccn1)N1CCSCC1

InChI Key InChIKey=FCGUSVKFZTVUQB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50290047   

TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290047(Pyridin-2-yl-carbamic acid 2-[6-(5-isopropyl-pyrid...)
Affinity DataIC50: 14nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290047(Pyridin-2-yl-carbamic acid 2-[6-(5-isopropyl-pyrid...)
Affinity DataIC50: 1nMAssay Description:Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article