BDBM50290041 CHEMBL70203::Pyridin-2-yl-carbamic acid 2-[6-(4-tert-butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-[2,2']bipyrimidinyl-4-yloxy]-ethyl ester

SMILES COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCOC(=O)Nc1ccccn1)-c1ncccn1

InChI Key InChIKey=RZTQQRCQEYQARM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50290041   

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290041(Pyridin-2-yl-carbamic acid 2-[6-(4-tert-butyl-benz...)
Affinity DataIC50: 6nMAssay Description:Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290041(Pyridin-2-yl-carbamic acid 2-[6-(4-tert-butyl-benz...)
Affinity DataIC50: 43nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290041(Pyridin-2-yl-carbamic acid 2-[6-(4-tert-butyl-benz...)
Affinity DataIC50: 6nMAssay Description:Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290041(Pyridin-2-yl-carbamic acid 2-[6-(4-tert-butyl-benz...)
Affinity DataIC50: 43nMAssay Description:Displacement of radioligand from ETB receptor in human placenta cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290041(Pyridin-2-yl-carbamic acid 2-[6-(4-tert-butyl-benz...)
Affinity DataIC50: 6nMAssay Description:Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290041(Pyridin-2-yl-carbamic acid 2-[6-(4-tert-butyl-benz...)
Affinity DataIC50: 43nMAssay Description:Displacement of radioligand from ETB receptor in human placenta cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed