BDBM50289702 CHEMBL3746059

SMILES NC(=O)C1CCN(CC1)c1nc(nc2CCN(Cc3ccccc3)Cc12)-c1ccccn1

InChI Key InChIKey=QXYYYFOCWWWMNZ-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50289702   

TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50289702(CHEMBL3746059)
Affinity DataEC50:  1.40E+3nMAssay Description:Corrector activity at CFTR F508-del mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2020
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50289702(CHEMBL3746059)
Affinity DataEC50:  1.41E+3nMAssay Description:Corrector activity at CFTR F508-del mutant (unknown origin) expressed in human CFBE41o cells harboring HS-YFP preincubated for 24 hrs followed by for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2020
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50289702(CHEMBL3746059)
Affinity DataEC50:  1.40E+3nMAssay Description:Corrector activity at human CFTR F508 deletion mutant expressed in FRT cells incubated for 25 mins with forskolin by YFP-based fluorescence analysis ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed