BDBM50289297 6-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-imidazo[2,1-b]thiazole::CHEMBL423576

SMILES CS(=O)(=O)c1ccc(cc1)-c1c(nc2sccn12)-c1ccc(F)c(F)c1

InChI Key InChIKey=LPFFZAPRSCUBPF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50289297   

TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289297(6-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vivo ability to inhibit cyclooxygenase-1 enzyme in human whole blood was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289297(6-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 2.20E+3nMAssay Description:In vivo ability to inhibit cyclooxygenase-2 enzyme in human whole blood was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289297(6-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 12nMAssay Description:In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article