BDBM50288550 Benzo[1,3]dioxol-5-yl-(1,2,3,4-tetrahydro-acridin-9-yl)-acetic acid methyl ester::CHEMBL102494

SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2CCCCc2nc2ccccc12

InChI Key InChIKey=OQUYJGQEHATGLA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50288550   

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288550(Benzo[1,3]dioxol-5-yl-(1,2,3,4-tetrahydro-acridin-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288550(Benzo[1,3]dioxol-5-yl-(1,2,3,4-tetrahydro-acridin-...)
Affinity DataIC50: 7.30E+3nMAssay Description:Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288550(Benzo[1,3]dioxol-5-yl-(1,2,3,4-tetrahydro-acridin-...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article