BDBM50288537 Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid methyl ester::CHEMBL320236

SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12

InChI Key InChIKey=OOTHGTPTLCSOEZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50288537   

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288537(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid met...)
Affinity DataIC50: 5.80E+3nMAssay Description:Compound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288537(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid met...)
Affinity DataIC50: 2.50E+5nMAssay Description:Compound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288537(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid met...)
Affinity DataIC50: 2.80E+3nMAssay Description:Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288537(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid met...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article