BDBM50288511 CHEMBL4171692

SMILES Cc1cnc(nc1Nc2cccc(c2)CO)Nc3cc(cc(c3)S(=O)(=O)C)N4CCN(CC4)C

InChI Key InChIKey=WKJVLTJTBZVAKC-UHFFFAOYSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50288511   

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288511(CHEMBL4171692)
Affinity DataEC50:  99nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288511(CHEMBL4171692)
Affinity DataIC50: 3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288511(CHEMBL4171692)
Affinity DataIC50: 929nMAssay Description:Inhibition of recombinant human JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 as substrate after 10 mins by cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288511(CHEMBL4171692)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human JAK3 (781 to 1124 residues) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 as substrate after 10 mins by cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2020
Entry Details Article
PubMed