BDBM50287722 CHEMBL436760::[4-(6-Bromo-1H-indol-3-yl)-1H-imidazol-2-yl]-(6-hydroxy-1H-indol-3-yl)-methanone::[5-(6-Bromo-1H-indol-3-yl)-1H-imidazol-2-yl]-(6-hydroxy-1H-indol-3-yl)-methanone::bromotopsentin::topsentin B2

SMILES Oc1ccc2c(c[nH]c2c1)C(=O)c1nc(c[nH]1)-c1c[nH]c2cc(Br)ccc12

InChI Key InChIKey=YHGQVXFIJGWOFP-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50287722   

TargetSortase family protein(Staphylococcus aureus)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50287722(topsentin B2 | [4-(6-Bromo-1H-indol-3-yl)-1H-imida...)
Affinity DataIC50: 4.03E+4nMAssay Description:Inhibitory activity against Sortase A from Staphylococcus aureusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetSortase family protein(Staphylococcus aureus)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50287722(topsentin B2 | [4-(6-Bromo-1H-indol-3-yl)-1H-imida...)
Affinity DataIC50: 3.96E+4nMAssay Description:Inhibition of Staphylococcus aureus SrtA using EDANS-Dabcyl as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAlpha-1B adrenergic receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287722(topsentin B2 | [4-(6-Bromo-1H-indol-3-yl)-1H-imida...)
Affinity DataKi:  740nMAssay Description:Binding affinity against human Alpha-1b adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetAlpha-1A adrenergic receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287722(topsentin B2 | [4-(6-Bromo-1H-indol-3-yl)-1H-imida...)
Affinity DataKi:  1.26E+4nMAssay Description:Compound was tested for its binding affinity towards CHO cells expressing human Alpha-1a adrenergic receptor by displacing [125I]HEAT (2-beta-(4-hydr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article