BDBM50286765 CHEMBL4159778

SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1cccc(N)n1

InChI Key InChIKey=NAKYNJKKYDJABY-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50286765   

TargetLeucine--tRNA ligase, cytoplasmic(Human)
Oxford Drug Design

Curated by ChEMBL
LigandPNGBDBM50286765(CHEMBL4159778)
Affinity DataIC50: 850nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetLeucine--tRNA ligase(Escherichia coli (strain K12))
Oxford Drug Design

Curated by ChEMBL
LigandPNGBDBM50286765(CHEMBL4159778)
Affinity DataIC50: 23nMAssay Description:Inhibition of Escherichia coli LeuRS expressed in Escherichia coli M15 cells assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetLeucine--tRNA ligase(Escherichia coli (strain K12))
Oxford Drug Design

Curated by ChEMBL
LigandPNGBDBM50286765(CHEMBL4159778)
Affinity DataKd:  14nMAssay Description:Displacement of IK-698 from Escherichia coli LeuRS by isothermal titration calorimetric calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetLeucine--tRNA ligase(Staphylococcus aureus (strain NCTC 8325 / PS 47))
Oxford Drug Design

Curated by ChEMBL
LigandPNGBDBM50286765(CHEMBL4159778)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Staphylococcus aureus LeuRS expressed in Escherichia coli M15 cells assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed