BDBM50286423 CHEMBL4174931

SMILES CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccccc3)[C@@H](C)C(F)(F)F)C2=O)c1

InChI Key InChIKey=LDPBOBQZOFLMLU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50286423   

TargetCytochrome P450 2C9(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50286423(CHEMBL4174931)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50286423(CHEMBL4174931)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50286423(CHEMBL4174931)
Affinity DataIC50: 990nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50286423(CHEMBL4174931)
Affinity DataIC50: 101nMAssay Description:Inhibition of p300/CBP in human PC3 cells assessed as reduction in acetylated H3K27 levels after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50286423(CHEMBL4174931)
Affinity DataIC50: 60nMAssay Description:Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2020
Entry Details Article
PubMed