BDBM50284614 2-Benzylidene-3-(3,5-dimethyl-benzyloxy)-1-aza-bicyclo[2.2.2]octane::CHEMBL435564

SMILES Cc1cc(C)cc(COC2C3CCN(CC3)\C2=C\c2ccccc2)c1

InChI Key InChIKey=HTLSINNHNFLIHS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50284614   

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284614(2-Benzylidene-3-(3,5-dimethyl-benzyloxy)-1-aza-bic...)
Affinity DataIC50: 129nMAssay Description:Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284614(2-Benzylidene-3-(3,5-dimethyl-benzyloxy)-1-aza-bic...)
Affinity DataIC50: 120nMAssay Description:Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284614(2-Benzylidene-3-(3,5-dimethyl-benzyloxy)-1-aza-bic...)
Affinity DataIC50: 615nMAssay Description:Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article