BDBM50283981 CHEMBL4161507

SMILES COc1cc(CN2CCN(CC2)c2cccc(CCC(=O)N3Cc4cnn(C)c4Nc4ccccc34)c2)cc(OC)c1

InChI Key InChIKey=HNYHLGSKADMCNE-UHFFFAOYSA-N

Data  2 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50283981   

TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50283981(CHEMBL4161507)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human OTR expressed in HEK293 cells assessed as induction of IP1 accumulation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50283981(CHEMBL4161507)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as induction of IP1 accumulation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50283981(CHEMBL4161507)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human OTR expressed in HEK293 cells assessed as inhibition of agonist-induced IP1 accumulation preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50283981(CHEMBL4161507)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50283981(CHEMBL4161507)
Affinity DataKi:  3.34E+3nMAssay Description:Displacement of [3H]-vasopressin from human vasopressin V1a receptor expressed in HEK293 cell membranes after 90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50283981(CHEMBL4161507)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-oxytocin from human OTR expressed in HEK293 cell membranes after 90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed