BDBM50282510 7-(4-Chloro-benzyloxy)-3,4-dimethyl-chromen-2-one::7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-one::CHEMBL274030

SMILES Cc1c(C)c(=O)oc2cc(OCc3ccc(Cl)cc3)ccc12

InChI Key InChIKey=LVUUTOUXLZZNQA-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50282510   

LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 12nMAssay Description:In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 0.600nMAssay Description:In vitro inhibitory activity against monoamine oxidase B (MAO-B) in rat brain homogenate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 2.60nMAssay Description:Inhibitory activity against monoamine oxidase BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 123nMAssay Description:Inhibitory activity against monoamine oxidase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 123nMAssay Description:Inhibitory effect on monoamine oxidase A, SD on IC50 values < 10%More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 2.57nMAssay Description:Inhibitory effect on Monoamine oxidase B, SD on IC50 values < 10%More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 1.48nMAssay Description:Inhibition of human supersomes MAOBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 2.57nMAssay Description:Inhibition of rat brain MAOBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human MAO-B using p-tyramine as substrate assessed as decrease in H2O2 production incubated for 15 mins by fluorimetric met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2018
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 6.77E+3nMAssay Description:Inhibition of recombinant human MAO-A using p-tyramine as substrate assessed as decrease in H2O2 production incubated for 15 mins by fluorimetric met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2018
Entry Details Article
PubMed
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat brain mitochondrial MAOB using kynuramine as substrate assessed as decrease in 4-hydroxyquinoline production by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2018
Entry Details Article
PubMed
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 123nMAssay Description:Inhibition of rat brain mitochondrial MAOA using kynuramine as substrate assessed as decrease in 4-hydroxyquinoline production by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2018
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Babu Banarasi Das Northern India Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50282510(7-(4-chlorobenzyloxy)-3,4-dimethyl-2H-chromen-2-on...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine chloride as substrate incubated for 5 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed