BDBM50282157 CHEMBL4161291

SMILES [H][C@]12C[C@H](N[C@@]1([H])CCCC2)C(=O)N[C@@H](CCCCN(C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1

InChI Key InChIKey=HPURZZOPLJWEKA-UHFFFAOYSA-N

Data  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50282157   

TargetPolycomb protein EED(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataIC50: 3.87E+3nMAssay Description:Inhibition of full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by 3-FAM labelled fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataKd:  1.14E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataIC50: 3.90E+3nMAssay Description:Displacement of 3-FAM from N-terminal 6His-tagged full length EED (unknown origin) expressed in Escherichia coli Rosetta2 BL21(DE3)pLysS incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataKd:  1.14E+3nMAssay Description:Binding affinity to N-terminal His-tagged full length EED (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataKd:  1.14E+3nMAssay Description:Binding affinity to N-terminal His-tagged full length EED (unknown origin) expressed in Rosetta2 BL21 (DE3) pLysS competent cells assessed as dissoci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed