BDBM50281305 CHEMBL4162206

SMILES COc1cc2c(NC3CCN(CC3)C(C)C)cc(nc2cc1OCCCN1CCCC1)C1CCCCC1

InChI Key InChIKey=FQOJFAZVDGPADJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50281305   

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50281305(CHEMBL4162206)
Affinity DataIC50: 0.700nMAssay Description:Competitive inhibition of human G9a using 40 to 2560 nM biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50281305(CHEMBL4162206)
Affinity DataIC50: 1.40E+3nMAssay Description:Non-competitive inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of 1 to 20 uM SAM by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50281305(CHEMBL4162206)
Affinity DataIC50: 619nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50281305(CHEMBL4162206)
Affinity DataIC50: 0.5nMAssay Description:Non-competitive inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of 2 to 640 uM SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50281305(CHEMBL4162206)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50281305(CHEMBL4162206)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human GLP using histone H3 peptide as substrate after 120 mins in presence of [3H]SAM by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed