BDBM50281167 CHEMBL4175712::US12162877, Compound 8::US20240034730, Compound 38

SMILES Oc1nn2ccccc2c1C(=O)Nc1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=BOURAKVVPNVQQX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50281167   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50281167(CHEMBL4175712 | US20240034730, Compound 38 | US121...)
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli BL21(DE3) assessed as inhibition of DC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50281167(CHEMBL4175712 | US20240034730, Compound 38 | US121...)
Affinity DataIC50: 1nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50281167(CHEMBL4175712 | US20240034730, Compound 38 | US121...)
Affinity DataIC50: 760nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent