BDBM50280646 2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5,6-dimethoxy-indan-1-one::CHEMBL168938

SMILES COc1cc2c(cc1OC)C(=O)/C(=C/C3CCN(CC3)Cc4ccccc4)/C2

InChI Key InChIKey=LPMOTUSFDTTWJL-UHFFFAOYSA-N

Data  2 KI  6 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50280646   

TargetAcetylcholinesterase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50280646(2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Acetylcholinesterase activity in mouse brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetBeta-secretase 1(Mouse)
Magna Graecia University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50280646(2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse BACE-1 preincubated for 10 mins followed by fluorescent peptide substrate addition measured for 30 mins by fluorescence plate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Magna Graecia University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50280646(2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human erythrocytes AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Magna Graecia University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50280646(2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5...)
Affinity DataIC50: 4.74E+3nMAssay Description:Inhibition of horse serum BuChE using butyrylthiocoline iodide as substrate incubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
University of Pretoria

Curated by ChEMBL
LigandPNGBDBM50280646(2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5...)
Affinity DataIC50: 420nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50280646(2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5...)
Affinity DataIC50: 697nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Magna Graecia University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50280646(2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5...)
Affinity DataKi:  35nMAssay Description:Non-competitive inhibition of human erythrocytes AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Lineweaver-Burk plot analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Magna Graecia University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50280646(2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5...)
Affinity DataKi:  2.44E+3nMAssay Description:Mixed inhibition of horse serum BuChE using butyrylthiocoline iodide as substrate incubated for 20 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed