BDBM50280445 (E)-2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]phenyl}-1-fluorovinylphosphonate

SMILES Nc1nc2n(Cc3ccccc3C=C(F)P([O-])([O-])=O)cnc2c(=O)[nH]1

InChI Key InChIKey=AEMSKSDTIXCPHB-UHFFFAOYSA-L

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50280445   

TargetPurine nucleoside phosphorylase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280445((E)-2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration against calf spleen purine nucleoside phosphorylase in the presence of 50 mM (pi) orthophosphonateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetPurine nucleoside phosphorylase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50280445((E)-2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl...)
Affinity DataIC50: 77nMAssay Description:Inhibitory concentration against human erythrocytic purine nucleoside phosphorylase in the presence of 50 mM (pi) orthophosphonateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetPurine nucleoside phosphorylase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280445((E)-2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory activity against calf spleen purine nucleoside phosphorylase in the presence of 1 mM (pi) orthophosphonateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetPurine nucleoside phosphorylase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50280445((E)-2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl...)
Affinity DataKi:  1.80nMAssay Description:Inhibitory activity against human erythrocytic purine nucleoside phosphorylase in the presence of 1 mM (pi) orthophosphonateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article