BDBM50279681 CHEMBL4168473

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)-n1cc(CN2CCC(C)CC2)nn1

InChI Key InChIKey=YGYGMNYVMRIARK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50279681   

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50279681(CHEMBL4168473)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2020
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50279681(CHEMBL4168473)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50279681(CHEMBL4168473)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2020
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50279681(CHEMBL4168473)
Affinity DataIC50: 703nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged c-MET cytoplasmic domain (956 to 1390 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2020
Entry Details Article
PubMed